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. 2021 Dec 8;22(24):13211. doi: 10.3390/ijms222413211

Figure 6.

Figure 6

Towards a model of cell hierarchies in gliomas. Single-cell transcriptomics-based links proposed for the developing human telencephalon (A), adult human telencephalon (C), and the potential similarities with IDHwt glioblastomas (B) and IDH1/2 gliomas (D). The nodes in (A) represent the cell types from human fetal telencephalic samples corresponding to different types of radial glia (RG), excitatory neuron progenitors (ENPs), excitatory neurons (ENs), inhibitory neuron progenitors (INPs), inhibitory neurons (INs), truncated RG (tRG), astrocytes (Astros), glial progenitor cells (GPCs) and oligodendrocyte progenitor cells (OPCs; shown as clusters in Figure 2). Nodes in (B) marked with (*) represent cell types with IDHwt glioblastoma-related mutations. Mesenchymal-like cells (Mesos). The nodes in (C) represent the cell types in the adult subventricular zone (SZV) samples corresponding to different types of adult neural stem cells (NSCs), such as quiescent (qNSCs) and activated neural stem cells (aNSCs), inhibitory neuron progenitors (INPs), inhibitory neurons (INs), astrocytes (Astros), glial progenitor cells (GPCs) and oligodendrocyte progenitor cells (OPCs; shown as clusters in Figure 3). Nodes in (D) marked with (*) represent cell types with IDH1/2 glioma-related mutations. GSC: glioma stem-like cells, OLC: oligo-lineage cells.