Table 3.
Pathway analysis of aqueous humor (AH) proteins using IPA tools.
| Canonical Pathways | Overlap of Proteins in the Single-Risk and Cataract Control Groups | Overlap of Proteins in the Double-Risk and Cataract Control Groups | Overlap of Proteins in the Single- and Double-Risk Groups |
|---|---|---|---|
| LXR/RXR Activation | 12 | 10 | 1 |
| FXR/RXR Activation | 12 | 10 | 1 |
| Acute-Phase Response Signaling | 11 | 11 | 1 |
| Clathrin-mediated Endocytosis Signaling | 12 | ||
| Atherosclerosis Signaling | 7 | ||
| Primary Immunodeficiency Signaling | 5 | ||
| IL-15 Signaling | 9 | 1 | |
| B Cell Receptor Signaling | 1 |
Single risk, patients with the DM or smoking risk factor; double risk, patients with both the DM and smoking risk factors; control, cataract patients with neither of these cataract risk factors.