Figure 2.

Membrane hyperpolarization and calcium signaling in myoblast differentiation. The sequential activity of EAG and Kir2.1 K⁺ channels leads to membrane hyperpolarization, which in turn is required for Ca²⁺ signaling. Ca²⁺ release from the ER, which leads to activation of SOCE, can contribute to the Ca²⁺ signal. Activity of the Cl⁻ channel VRAC contributes to hyperpolarization by an unknown mechanism. See the main text for details.