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Reagents and conditions: (a) BBr3 1 M DCM, dry DCM, −78 °C to rt, overnight, 87%; (b) TBDMSCl, imidazole, DMF, 0 °C to rt, overnight, 81%; (c) TBDMSCl, imidazole, DMF, 0 °C to rt, overnight, 74%; (d) CBr4, PPh3, DCM, 0 °C to rt, 1 h, 83%, (e) LDA, THF, −78 °C, 1 h, 91%; (f) Pd(PPh3)4, CuI, TEA, 90 °C, 8 h; (g) KF, MeOH/THF, rt, overnight, 38% over 2 steps.
