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. 2021 Dec 13;22(24):13367. doi: 10.3390/ijms222413367

Figure 1.

Figure 1

Sphingosine-1-phosphate (S1P) levels in plasma of estrogen receptor-positive breast cancer patients. S1P levels were determined by mass spectrometry and compared between patients of <60 years and ≥60 years (A); premenopause (Pre) and postmenopause (Post) (B); body mass index (BMI) <25 or ≥25 (C); negative (Neg) and positive (Pos) for progesterone receptor (PgR) (D); negative and positive for HER2 expression/amplification (E); NSAS nuclear grade (NG) 1, 2, or 3 (F); negative and positive for lymphatic invasion (ly) (G); negative and positive for vascular invasion (v) (H); Ki-67 labeling index <20 and ≥20 (I); pathological primary tumor (pT) 1 and 2–4 (J); pathological regional lymph node (pN) 0 and 1–3 (K); pathological stage (pStage) 0, I, II, and III (L). Horizontal lines indicate median values. The Mann–Whitney U test was performed for statistical analysis, in which all tests were two-sided, and p-values < 0.05 were considered statistically significant (shown in red color).