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. 2001 Jun;21(11):3807–3819. doi: 10.1128/MCB.21.11.3807-3819.2001

FIG. 2.

FIG. 2

Phenotypes of STAM1−/− mice. (A) Growth curves for STAM1+/+ (male, n = 26; female, n = 9), STAM1+/− (male, n = 36; female, n = 30), and STAM1−/− (male, n = 21; female, n = 12) mice. One male mouse died at 7 weeks, and four male mice and two female mice died at 8 weeks. Error bars indicate standard errors. (B) Survival curves for STAM1+/+ (male, n = 21; female, n = 31), STAM1+/− (male, n = 27; female, n = 31), and STAM1−/− (male, n = 21; female, n = 30) mice. (C) Abnormal limb reflex of STAM1−/− mice. STAM1+/+ mice extend their legs when lifted by the tail (left panel), whereas STAM1−/− mice lack this reflex and show clasping of the hind limbs (right panel). The mice were 4-week-old littermates. (D) Priapism in STAM1−/− mice. Priapism was observed in male STAM1−/− mice surviving for more than 8 weeks. About 70% of STAM1−/− male mice suffered from priapism during their lives.