Table 1.

COX2 inhibitory properties of fucoidans isolated from brown seaweeds.

Seaweed	Tested Organism	Effect	Reference
Chnoospora minima	LPS-activated RAW 264.7 macrophages	COX2 inhibition	[27]
Chnoospora minima and Sargassum polycystum	LPS-activated RAW 264.7 macrophages	Inhibit LPS-induced PGE2 secretion	[26]
Commercial grade fucoidan	Male Wistar albino rats	COX2 inhibition	[24]
Commercial grade fucoidans	BALB/c mice and RAW 264.7 macrophages	Inhibit LPS-induced COX2 secretion	[23]
Fucus vesiculosus, Undaria pinnatifida, and Macrocystis pyrifera	Chondrocytes and Synoviocytes	Inhibit IL-1β-induced COX2 secretion	[21]
Fucus vesiculosis	RAW 264.7 macrophages and zebrafish embryos	Inhibit LPS-induced PGE2 secretion	[22]
Hikizia fusiforme	RAW 264.7 macrophages	COX2 inhibition	[29]
Sargassum thunbergii	RAW 264.7 macrophages	Downregulation of LPS-activated COX2 expression	[28]
Turbinaria ornate	RAW 264.7 macrophages and zebrafish embryos	COX2 inhibition	[25]
Undaria pinnatifida	Rabbit articular chondrocytes	Downregulation of COX2 observed in chondrocytes	[20]
Undaria pinnatifida	Arthritic rats	Downregulation of COX2	[20]