Table 4.
The composition of drug-loaded microemulsions with different surfactants.
| Drug | Oil | Surfactant | HLB | Cosurfactant | Water | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Code | GEN | CAP | LAB | CEL | T80 | B30 | S20 | THP | Water | |||
| ME01 | 1.0 | 5.0 | 15 | - | - | - | - | 12 | 32.0 | 47.0 | ||
| ME02 | 1.0 | 5.0 | 15 | - | - | - | 12 | 32.0 | 47.0 | |||
| ME03 | 1.0 | 5.0 | - | 15 | - | - | 15 | 32.0 | 47.0 | |||
| ME04 | 1.0 | 5.0 | 7.5 | 7.5 | - | - | 14 | 32.0 | 47.0 | |||
| ME05 | 1.0 | 5.0 | - | 12.5 | 2.5 | - | 14 | 32.0 | 47.0 | |||
| ME06 | 1.0 | 5.0 | 5.0 | - | 10.0 | - | - | 14 | 32.0 | 47.0 | ||
| ME07 | 1.0 | 5.0 | - | 12.7 | - | 2.3 | 14 | 32.0 | 47.0 | |||
| ME08 | 1.0 | 5.0 | - | - | 4.3 | 10.7 | - | 11 | 32.0 | 47.0 | ||
| ME09 | 1.0 | 5.0 | - | - | 6.8 | 8.2 | - | 12 | 32.0 | 47.0 | ||
| ME10 | 1.0 | 5.0 | - | - | 9.5 | 5.5 | - | 13 | 32.0 | 47.0 | ||
| Drug | Oil | Cosurfactant | Surfactant | Water | ||||||||
| Code | GEN | CAP | THP | IPA | DPG | HEX | PEN | PEG | HLB | T80 | B30 | Water |
| ME11 | 1.0 | 5.0 | 22.0 | 10.0 | - | - | - | 11 | 4.3 | 10.7 | 47.0 | |
| ME12 | 1.0 | 5.0 | 22.0 | - | 10.0 | - | - | - | 11 | 4.3 | 10.7 | 47.0 |
| ME13 | 1.0 | 5.0 | 22.0 | - | - | 10.0 | - | - | 11 | 4.3 | 10.7 | 47.0 |
| ME14 | 1.0 | 5.0 | 22.0 | - | - | - | 10.0 | - | 11 | 4.3 | 10.7 | 47.0 |
| ME15 | 1.0 | 5.0 | 22.0 | - | 10.0 | 10.0 | 11 | 4.3 | 10.7 | 37.0 | ||
| ME16 | 1.0 | 5.0 | 22.0 | - | 10.0 | 15.0 | 11 | 4.3 | 10.7 | 32.0 | ||
| ME17 | 1.0 | 5.0 | 22.0 | - | 10.0 | 20.0 | 11 | 4.3 | 10.7 | 27.0 | ||
The total amount of each formulation was 100 g. GEN, Genistein; CAP, Capryol 90; LAB, Labrasol; CEL, Cremophor EL; T80, Tween 80; B30, Brij 30; S20, Span20; THP, Transcutol HP; IPA, isopropyl alcohol; DPG, Dipropylene Glycol; HEX, 1,2-hexanediol; PEN, 1,5-pentanediol; PEG, Polyethylene Glycol 400; HLB, hydrophilic-hydrophobic balance.