Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 10;13(12):2132. doi: 10.3390/pharmaceutics13122132

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Detailed scheme of the structure of SSTR2-expressing tissue incorporating the in vivo alpha particle generator model and relevant pharmacokinetic parameters of free ²¹²Bi. [²¹²Pb]Pb-SSTA and [²¹²Bi]Bi-SSTA are assumed to follow the same PK throughout the tissue. Free ²¹²Bi in the vasculature binds linearly with RBC and HWPP followed by free ²¹²Bi diffusion and uptake by tissue cells. The free daughter ²⁰⁸Tl is assumed to have the same permeability surface area product as that for free ²¹²Bi so that it diffuses between interstitial and vascular compartments and redistributes in the circulation. The alpha-emitting ²¹²Po decays at the site of its production.