Table 1.
Pharmacokinetic parameter values obtained from the 212Pb-SSTA-PBPK model fit to experimental data [4].
| Parameter (Unit) | Tissue | SAAM II | Simbiology |
|---|---|---|---|
| Estimated Value | |||
| SSTR2 density (nmol·L−1) | Kidneys | 3.52 ± 0.07 | 3.52 |
| Liver | 0.17 ± 0.04 | 0.16 | |
| Spleen | 0.73 ± 0.07 | 0.73 | |
| Lung | 1.77 ± 0.14 | 1.77 | |
| Pancreas | 6.18 ± 0.94 | 6.18 | |
| Tumor | 11.73 ± 2.97 | 11.73 | |
| Perfusion (mL·min−1·g−1) | Tumor | 0.09 ± 0.03 | 0.09 |
| Sorting rate (min−1) | SSTR2-expressing tissues | 0.0076 ± 0.0003 | 0.0076 |
| Release rate (min−1) | Pancreas | 0.0011 ± 0.0002 | 0.0011 |
| Kidneys | 0.000380 ± 0.000001 | 0.000380 | |