Table 2.
Total absorbed dose coefficients (ADC) and the contributions of the in vivo alpha particle generator [212Pb]Pb-DOTAMTATE and its radioactive decay products to the total absorbed doses in SSTR2-expressing and non-SSTR2-expressing tissues.
| Tissue | ADC (Gy/MBq) | Contribution to the Total Absorbed Dose per Tissue (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Conjugated Radionuclides | Free Radionuclides | |||||||||
| 212Pb | 212Bi | 212Bi | 212Po | 212Bi | 208Tl | 212Bi | 212Po | |||
| Beta | Alpha | Beta | Alpha | |||||||
| SSTR2-expressing tissues | Tumor | 248 | 5 | 11 | 18 | 45 | 2 | 6 | 3 | 8 |
| Kidneys | 134 | 6 | 11 | 18 | 45 | 2 | 6 | 3 | 8 | |
| Pancreas | 116 | 6 | 11 | 17 | 44 | 2 | 6 | 4 | 9 | |
| Liver | 9 | 5 | 9 | 14 | 35 | 5 | 6 | 7 | 19 | |
| Lung | 65 | 6 | 11 | 18 | 45 | 2 | 6 | 3 | 8 | |
| Spleen | 28 | 6 | 11 | 17 | 44 | 2 | 6 | 4 | 10 | |
| Ad | 89 | 6 | 11 | 18 | 45 | 2 | 6 | 3 | 9 | |
| GI | 85 | 5 | 11 | 18 | 45 | 2 | 6 | 3 | 9 | |
| Non-SSTR2-expressing tissues | Skin | 1.8 | 9 | 11 | 16 | 42 | 2 | 6 | 4 | 9 |
| Bone | 2.7 | 3 | 3 | 5 | 14 | 10 | 7 | 16 | 41 | |
| Muscle | 0.6 | 11 | 11 | 18 | 46 | 1 | 7 | 2 | 4 | |
| Heart | 3.6 | 2 | 14 | 23 | 58 | 0 | 1 | 0 | 1 | |
| Brain | 0.1 | 12 | 11 | 17 | 43 | 2 | 6 | 3 | 7 | |
| Fat | 1.0 | 9 | 9 | 14 | 36 | 1 | 28 | 1 | 3 | |
| RB | 1.0 | 11 | 11 | 18 | 45 | 1 | 6 | 2 | 5 | |