Table 1.
Summary of studies on NQO1 and various disease entities.
| Author | Published (Year) | Role of NQO1 | Reference |
|---|---|---|---|
| Atherosclerosis and Cardiovascular Diseases | |||
| Lee, et al. | 2007 | Reduced TNF-α-induced migration of human VSMCs | [131] |
| Kim, et al. | 2009 | Prevented arterial restenosis | [132] |
| Han, et al. | 2009 | C609T variant was associated with carotid artery plaques in T2DM patients | [133] |
| Isbir, et al. | 2008 | C609T variant was related to higher IL-6 levels | [133] |
| Martin, et al. | 2009 | Lack of activity of NQO1 was associated with elevation of CHD and CRP | [134] |
| Insulin Resistance and Diabetes Mellitus | |||
| Sun, et al. | 2020 | Astaxanthin reduced oxidative stress and insulin resistance | [135] |
| Wang, et al. | 2006 | C609T variant was not associated with DM in Chinese subjects | [136] |
| Kristiansen, et al. | 1999 | C609T variant was not related to DM in Danish subjects | [137] |
| Gaikward, et al. | 2001 | NQO1-null mice were insulin resistant | [138] |
| Metabolic Syndrome | |||
| Hwang, et al. | 2009 | β-Lapachone showed improvement of metabolic syndrome | [101] |
| Gaikward, et al. | 2001 | NQO1-null mice exhibited higher NAD(P)H/NAD(P)+, higher TG level, and lower abdominal fat | [138] |
| Palming, et al. | 2007 | NQO1 was correlated with adiposity and liver dysfunction | [139] |
| Aging | |||
| Lee, et al. | 2012 | β-Lapachone prevented health decline in aged mice | [100] |
| Kim, et al. | 2019 | β-Lapachone improved age-related hearing impairment | [140] |
| Alzheimer’s Disease | |||
| SantaCruz, et al. | 2004 | NQO1 was located adjacent to senile plaques | [141] |
| Wang, et al. | 2000 | NQO1 activity was increased in AD | [142] |
| Luo, et al. | 2016 | C609T variant was associated with risk of AD in Chinese subjects | [143] |
| Martinez-Limon, et al. | 2016 | NQO1 could bind together with β-amyloid fibrils | [144] |
Abbreviations—TNF: tumor necrosis factor; VSMCs: vascular smooth muscle cells; T2DM: type 2 diabetes mellitus; IL: interleukin; CHD: coronary heart disease; CRP: C-reactive protein; DM: diabetes mellitus; TG: triglyceride; AD: Alzheimer’s disease.