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. 2021 Dec 7;22(24):13197. doi: 10.3390/ijms222413197

Figure 3.

Figure 3

Body weight changes in male rats that were injected with Lepvv or GFPvv on day 8 followed by injection with citrate buffer or STZ (to induced diabetes) on day 17. (A) Profile of body weight (g, mean ± SEM) in diabetic and non-diabetic rats treated with Lepvv or GFPvv. Citrate + GFPvv (n = 7); STZ + GFPvv (n = 6); Citrate + Lepvv (n = 5) and STZ + Lepvv (n = 7) are represented. Data were analyzed using linear mixed models as described under Statistics. “a” indicates significant difference between diabetic rats that received Lepvv and non-diabetic rats that received GFPvv (p < 0.0001). Differences between diabetic and non-diabetic animals progressively increased towards the end of observation (p < 0.05–p < 0.0001). (B) Average body weight on the 9th day after STZ/citrate injection (g, mean ± SEM). Data were analyzed by 2-way ANOVA followed by Tukey’s multiple comparisons test. Diabetic rats lost more weight compared to the GFPvv treated non-diabetic group. Lepvv treatment caused a dramatic reduction in body weight in diabetic animals, which was still less when compared to non-diabetic rats treated with Lepvv. * indicates p < 0.05; ** p < 0.01 and *** p < 0.001.