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. 2021 Dec 19;14(12):1330. doi: 10.3390/ph14121330

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SG2 shows a safe toxicological profile in an in vitro panel. A panel of toxicological assays were performed to test (A) SG2 behaviour over cytotoxicity (U2-OS, HEK293, MCF-7, hTERT), (B) epigenetic modulation (HDAC6, HDAC8, SIRT7), and off-target liability (PDE4C1, Aurora B kinase). All assays were performed at 10 µM in triplicate. Raw data were normalized over positive and negative control and reported as percentage of inhibition. In no assay SG2 showed a percentage of inhibition higher than 40%, where in this profiling a value < 50% is generally considered acceptable.