Skip to main content
. 2021 Dec 19;14(12):1330. doi: 10.3390/ph14121330

Figure 6.

Figure 6

SG2 improves learning ability in the 5xFAD mouse model of AD. (A) Analysis of MWM learning curve showed no significant differences between experimental groups (repeated measures ANOVA, Time F (3,105) = 21.57, p < 0.0001, Treatment F (3,35) = 0.3141, p = 0.82, Time × Treatment F (9,105) = 1.553, p = 0.14). (B) Learning index analysis demonstrated an improved performance of Tg-SG2 mice compared to Tg-Sal to find the hidden platform. For statistical tests, One-Way ANOVA was used p < 0.02 * (C) The time needed to reach the platform area (C) and the number of entries in the target area (D) were not statistically different between experimental groups. (E) The analysis of search strategy showed an increase in spatially targeted strategies in Tg-SG2 mice compared to Tg-Sal mice (Fisher’s test). Data are shown as mean ± SEM. Experimental groups: Wt-Sal, n = 10; Wt-SG2, n = 10; Tg-Sal, n = 10: Tg-SG2, n = 9.