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. 2021 Dec 6;11(12):1310. doi: 10.3390/jpm11121310

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RR cells migrate faster than non-RR cells, and the migration potential in all cell types was enhanced after treatment with exosomes isolated from RR cell lines. Migration potential was assayed by an in vitro wound-healing assay in (A) REM134, (B) REM134 RR, (C) MDA-MB-231 and (D) MDA-MB-231 RR cells. The indicated cell line was treated with either PBS or exosomes isolated from either non-RR (50 μg/mL) or RR corresponding cells (50 μg/mL). (i) Light microscopy images of cell migration at the indicated time points are shown. (ii) Graphical representation of relative migration compared to the PBS control at the indicated time points. Three biological repeats were performed, and a two-sample t test was used for the analysis of data. Error bars indicate ±SD. ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.00001.

RR cells migrate faster than non-RR cells, and the migration potential in all cell types was enhanced after treatment with exosomes isolated from RR cell lines. Migration potential was assayed by an in vitro wound-healing assay in (A) REM134, (B) REM134 RR, (C) MDA-MB-231 and (D) MDA-MB-231 RR cells. The indicated cell line was treated with either PBS or exosomes isolated from either non-RR (50 μg/mL) or RR corresponding cells (50 μg/mL). (i) Light microscopy images of cell migration at the indicated time points are shown. (ii) Graphical representation of relative migration compared to the PBS control at the indicated time points. Three biological repeats were performed, and a two-sample t test was used for the analysis of data. Error bars indicate ±SD. ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.00001.