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. 2021 Dec 7;13(50):59673–59682. doi: 10.1021/acsami.1c17823

Figure 3.

Figure 3

(A) Inhibition of the Aβo aggregation kinetics and (B) disassembling of Aβf fibrils evaluated using the ThT assay. Ga, 2G0-GaOH, 2G1-GaOH, and 3G1-GaOH, inhibited the Aβ fibril elongation and promote the rupture of Aβf fibrils at different molar ratios: 1:0.5, 1:1, and 1:2. Dendrimers were mixed with Aβo in the lag-phase of the Aβ fibril formation or with Aβf in the plateau phase, and fluorescence was measured over 8 days (Aβo) or 5 days (Aβf). All experiments were performed at room temperature.