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. 2021 Dec 6;11(12):3306. doi: 10.3390/nano11123306

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The cytotoxicity and cell proliferation were investigated by CCK-8 and SEM. (a) SEM images of MC3T3-E1 cells on Pac@PLGA MS/HA coated Ti for 1, 3, and 5 d. (b)The cytotoxicity of Pac-525 on MC-3T3 cells. (c) The increased viability of MC3T3-E1 cells on Ti, HA coated Ti, and Pac@PLGA MS/HA coated Ti (* p > 0.05).