Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cancer cells develop resistance to Photodynamic therapy through altered genetic profiling, increase in DNA damage repair mechanism, increase in AKT/mTOR signaling and expression of ROS-scavenger proteins. In the mitochondria, PDT can lead to dysregulation of antiapoptotic Bcl-2 protein at the cell membrane, overexpression of efflux proteins such as the P-glycoproteins, and autolysosome formation through recycling of cytoplasmic content for cell survival.
