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. 2021 Dec 9;13(12):2126. doi: 10.3390/pharmaceutics13122126

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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µCT results of the mannitol formulation. Reconstructed 3D image of the dried product layer obtained via a high (panel A) and slow spin-freezing rate (panel B). The cumulative distribution of the equivalent diameter (ED), hydrodynamic diameter (HD) and maximum opening (MO) of the dried product layer obtained via a high (panel C) and slow spin-freezing rate (panel D). The cumulative distribution of the hydrodynamic diameter of the dried product layer obtained via a high (panel E) and slow spin-freezing rate in function of used threshold (panel F).