. 2021 Nov 10;3(1):vdab166. doi: 10.1093/noajnl/vdab166

Table 1.

Primary Lung Cancer and Brain Metastases PD-L1 Study Details and Patient Characteristics

Author	Year	Institution	Years	Evidence Quality	N	Median Age	Sex		Smoking status		Histology		BM Timing		CT prior Lung Sx		RT prior Lung Sx		Steroid prior BM Sx		CT prior BM Sx		RT prior BM Sx
							Male	Female	Smoker	Never smoker	NSCLC	SCLC	Synchronous	Metachronous	Yes	No	Yes	No	Yes	No	Yes	No	Yes	No
Mansfield et al.¹⁶	2016	Single-center	1994-2015	Low	73	61	40	33	58	15	56	17	8	5	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Bherghoff et al. ¹⁷	2016	Single-center	1990-2010	Low	32	58	NA	NA	NA	NA	0	32	NA	NA	NA	NA	NA	NA	NA	NA	15	17	3	29
Takamori et al. ¹⁸	2018	Multi-center	2005-2016	Low	15	64	21	11	23	9	30	2	NA	NA	3	12	NA	NA	NA	NA	NA	NA	13	2
Zhou et al. ¹⁹	2018	Single-center	2006-2014	Low	25	57	18	7	7	5	NA	NA	11	14	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Teglasi et al. ²⁰	2019	Single-center	NA	Low	61	60	30	31	56	5	NA	NA	NA	NA	4	57	2	59	37	15	32	29	5	56
Batur et al. ¹⁰	2019	Multi-center	NA	Low	24	NA	20	4	NA	NA	22	2	24	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA

BM, brain metastasis; CT, chemotherapy; N, number; NA, not available; NSCLC, non-small cell lung cancer; RT, radiotherapy; SCLC, small cell lung cancer; Sx, surgery.