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. 2021 Dec 20;13(12):2198. doi: 10.3390/pharmaceutics13122198

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Treatment of insomnia rats with melatonin microneedles: (a,b) pictures of a rat treated with MT/SF@MNs, (c) pictures of rat skin after removal of MN, and (d) curves of blood melatonin concentration over time.