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. 2021 Dec 9;22(24):13255. doi: 10.3390/ijms222413255

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characterization of Pi*M and PI*Z transgenic mice. (A) Enzyme-linked immunosorbent assay (ELISA) was used to measure human alpha-1 antitrypsin (hAAT) from the plasma of wild-type, Pi*M, and Pi*Z transgenic mice (n = 6); (B) PAS-D staining using immunohistochemistry on liver tissue of wild-type, Pi*M, and Pi*Z mice (top row). Neutral lipids and lipid droplets were assessed in Pi*Z transgenic mice and compared to Pi*M and wild type using H&E and Oil Red O staining, respectively (middle and bottom rows). (C) Hepatic total cholesterol and (D) triglycerides (TG) quantified by colorimetric assay from the Pi*M and Pi*Z mice liver tissue. ** p < 0.001, **** p < 0.0001.