Table 4.
Applications of nanoparticle in N2B delivery for treatment of stroke.
| Drug | Nanocarrier | Surfactant/Co-Surfactant | Surface Modification | Size, nm |
Z-potential, mV |
PDI | EE, % |
DTE, % |
DTP, % |
Ref. |
|---|---|---|---|---|---|---|---|---|---|---|
| Thymoquinone | PLGA Nanoparticle | - | Chitosan | 183.5 ± 8.2 | +33.63 ± 2.25 | 0.257 ± 0.02 | 73.2 ± 2.6 | 524.17 | 80.47 | [225] |
| NR2B9c | PLGA Nanoparticle | Sodium cholate | WGA/PEG | ~139 | −23.3 | <0.2 | ~50 | ~150 | 78.58 | [226] |
| Curcumin | PNIPAM Nanoparticle | - | - | 92.46 ± 2.8 | -16.2 ± 1.42 | 0.191 ± 0.052 | 84.63 ± 4.2 | 659.23 ± 83.59 | 84.03 ± 1.81 | [227] |
| Demethoxycurcumin | - | - | 91.23 ± 4.2 | -15.6 ± 1.33 | 0.183 ± 0.063 | 84.71 ± 3.99 | 667.84 ± 85.12 | 85.23 ± 2.19 | ||
| Bisdemethoxycurcumin | - | - | 94.28 ± 1.91 | −16.6 ± 1.21 | 0.142 ± 0.046 | 85.73 ± 4.31 | 677.12 ± 289.99 | 85.47 ± 2.49 |
Abbreviations: PDI: polydispersity index; EE: Encapsulation efficiency; DTE: Drug targeting efficiency; DTP: Direct transport percentage; PEG: polyethylene glycol; PLGA: poly lactic-co-glycolic acid; PNIPAM: Poly-N-isopropylacrylamide; WGA: wheat germ agglutinin.