Table 2.

Nuclear targets and impact of S-nitrosylation in tumor cells.

Nuclear Protein Target	Function	Tumor
STAT3	Decrease of STAT3 activity, increase of apoptosis Decrease of STAT3 phosphorylation and activation	Multiple myeloma Head and neck carcinoma [139,141]
p53	Increase of stability	Lung cancer [149]
NF-kB	Decrease of NF-kB activity, increase of apoptosis Inhibition of NF-kB DNA binding Impairment of NF-kB nuclear translocation, prevention of EMT Impairment of tumor cell adhesion and extravasation	Multiple myeloma Colon cancer Prostate cancer Breast cancer and Melanoma [139,140,142,143]
YY1	Prevention of YY1 activation, impairment of EMT	Prostate cancer [142]
Snail	Prevention of Snail activation, impairment of EMT	Prostate cancer [142]
β-catenin	Inactivation of β–catenin/TCF4 transcriptional activity, repression of cyclin D1, growth inhibition	Leukemia Colon cancer [144,145]
HIF-1 α	Protein stabilization, induction of VEGF expression	Breast cancer [146,147,148]
HDAC2	Enhancement of H4 acetylation, inhibition of interferon-α-stimulated genes expression	Melanoma [154]