Table 4.
Ligands for PRRs in the treatment of hematopoietic diseases. References in the text.
| Group of PRRs | PRR | Ligand | Hematopoietic Disease |
|---|---|---|---|
| TLR | TLR2 TLR4 TLR9 |
BCG | Acute myeloid leukemia |
| TLR3 | polyI:C, polyICLC |
Non-Hodgkin lymphomas, especially cutaneous T-cell lymphoma, low-grade B-cell lymphoma | |
| TLR4 | LPS | Non-Hodgkin lymphomas | |
| TLR4 | G-100 | Follicular lymphoma | |
| TLR7 | 852A | Acute myeloid leukemia, acute lymphoblastic leukemia, Non-Hodgkin lymphomas, Hodgkin lymphoma, Multiple myeloma | |
| TLR8 | VTX-2337 | Low-grade B-cell lymphoma | |
| TLR9 | CpG 7909 | Non-Hodgkin lymphoma, especially cutaneous T-cell lymphoma, Chronic lymphocytic leukemia | |
| NLR | NLRP3 | anthocyanin | Non-hematological malignancies: hepatocellular carcinoma, oral squamous cell carcinoma |
| RLR | RIG-I | 5’ppp-siRNA for Bcl-2 | Non-hematological malignancies: malignant melanoma |
| RIG-I | 5’ppp-siRNA for TNF-β | Non-hematological malignancies: pancreatic cancer | |
| MDA5 | dsDNA-poly I:C | Non-hematological malignancies: ovarian cancer |
BCG- Bacillus Calmette-Guerin, LPS- lipopolysaccharide.