Figure 3.

(A,C) represent an inferred enriched protein–protein interactions (PPI) network for cells stressed with MnCl₂ and Mn(II)Cit, respectively; p-value < 1.0 × 10⁻¹⁶. More than 85% of these interactions are derived experimentally. The predicted PPIs were calculated with high confidence score (0.9) and proteins/genes with no connections were removed. (B) Overlapping representation of 45 pathways that were affected by MnCl₂ and Mn(II)Cit. These interactions can be categorized in Protein Synthesis, Cell Metabolism, Cell Signaling, Neurodevelopment, and Neurodegeneration groups.