Table 2.
Enriched cellular pathways influenced by MnCl2 in RA-differentiated SH-SY5Y cells, after gene ontology analysis using the String database.
| Cell Pathways | Term Description | Observed | Background | FDR |
|---|---|---|---|---|
| Gene Count | Gene Count | |||
| Protein Synthesis | Peptide chain elongation | 75 | 86 | 4.37 × 10−92 |
| Viral mRNA Translation | 75 | 86 | 4.37 × 10−92 | |
| SRP-dependent cotranslational protein targeting to membrane | 78 | 109 | 1.15 × 10−91 | |
| Eukaryotic Translation Termination | 75 | 90 | 1.22 × 10−91 | |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 75 | 92 | 2.25 × 10−91 | |
| Formation of a pool of free 40S subunits | 75 | 98 | 5.96 × 10−90 | |
| L13a-mediated translational silencing of Ceruloplasmin expression | 75 | 107 | 5.93 × 10−88 | |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 75 | 108 | 9.04 × 10−88 | |
| Ribosome | 76 | 130 | 3.15 × 10−84 | |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 75 | 112 | 6.29 × 10−87 | |
| Major pathway of rRNA processing in the nucleolus and cytosol | 76 | 179 | 1.10 × 10−76 | |
| Metabolism of amino acids and derivatives | 77 | 354 | 2.98 × 10−59 | |
| Metabolism of RNA | 78 | 652 | 7.72 × 10−43 | |
| Formation of the ternary complex and subsequently the 43S complex | 31 | 49 | 1.27 × 10−34 | |
| Translation initiation complex formation | 31 | 55 | 1.85 × 10−33 | |
| Ribosomal scanning and start codon recognition | 31 | 55 | 1.85 × 10−33 | |
| Metabolism of proteins | 102 | 1948 | 1.12 × 10−27 | |
| Biosynthesis of amino acids | 9 | 72 | 5.98 × 10−05 | |
| Cell Metabolism | Selenocysteine synthesis | 75 | 90 | 1.22 × 10−91 |
| Selenoamino acid metabolism | 76 | 112 | 2.37 × 10−88 | |
| Metabolism | 137 | 2032 | 6.11 × 10−52 | |
| Oxidative phosphorylation | 26 | 131 | 9.48 × 10−18 | |
| The citric acid (TCA) cycle and respiratory electron transport | 28 | 173 | 7.83 × 10−18 | |
| Thermogenesis | 29 | 228 | 1.68 × 10−15 | |
| Complex I biogenesis | 17 | 55 | 8.42 × 10−15 | |
| Metabolic pathways | 50 | 1250 | 2.11 × 10−08 | |
| Glycolysis/Gluconeogenesis | 12 | 68 | 5.27 × 10−08 | |
| Fructose and mannose metabolism | 9 | 33 | 1.85 × 10−07 | |
| Metabolism of carbohydrates | 20 | 266 | 2.71 × 10−07 | |
| Carbon metabolism | 10 | 116 | 2.90 × 10−04 | |
| Cell Signaling | Retrograde endocannabinoid signaling | 18 | 148 | 2.25 × 10−09 |
| HIF-1 signaling pathway | 14 | 98 | 3.22 × 10−08 | |
| Negative regulation of MAPK pathway | 6 | 40 | 1.00 × 10−03 | |
| Neurodevelopment | Axon guidance | 79 | 541 | 3.00 × 10−49 |
| Neurodegeneration | Parkinson’s disease | 26 | 142 | 3.69 × 10−17 |
| Alzheimer’s disease | 20 | 168 | 3.22 × 10−10 | |
| Huntington’s disease | 19 | 193 | 1.57 × 10−08 |
False Discovery Rate—FDR.