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. 2021 Nov 27;13(12):2379. doi: 10.3390/v13122379

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Virus-induced modulation of the Janus kinase–signal transducer and transcriptional activator (JAK-STAT) signaling pathway. Viruses encode several factors that target specific steps in the JAK-STAT signaling pathway through diverse evasion mechanisms to subvert the host immune response. Viral proteins are highlighted in bold and the viruses in parentheses. EBOV, Ebola virus; DENV, dengue virus; HCV, hepatitis C virus; HIV-1, human immunodeficiency virus type 1; HPV16, human papillomavirus type 16; HSV-1, herpes simplex virus type 1; HSV-2, herpes simplex virus type 2; IAV, Influenza A virus; MV, measles virus; RoV, rotavirus; VACV, vaccinia virus; VAR, variola “smallpox” virus; VZV, varicella-zoster virus; ZIKV, Zika virus.