Figure 1.

Experimental SCID mouse model of chronic cryptosporidiosis and neoplasia. (A) Pattern of oocyst shedding (oocysts/g of feces) in mice at days 45 (blue dots) and 93 PI (red dots) wherein each dot represents individual mouse. The line in each pattern corresponds to the geometric mean of oocyst shedding per group. (B) Histological examination of C. parvum uninfected (i–iii) and infected (ii–iv) ileo-cecal regions at days 45 and 93 PI. Presence of significant cytonuclear atypia and appearance of intra-mucosal adenocarcinoma are observed at day 45 PI (black arrow). Desmoplastic reaction is also reported around the invasive neoplastic glands (white arrow) at day 93 PI.