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Study design and device overview (a) A total of 8 rats were each implanted with 2 textured silicone devices containing a standard HA gel −/+ VEGF microspheres, n = 4 per group. (b) Schematic of exploded rat-sized (10 × 20 × 1.2 mm) macroencapsulation device. a: Non-woven macro-porous pro-angiogenic coiling b: Microporous silicone blood barrier membrane c: Luer lock input nozzle d: Stopper (with break-off tab) e: Input tube f: Pouch inner structure g: Pouch perimeter.
