Figure 2.

Two major modes of HSV-1 spread. For simplicity, only the late cytoplasmic stages of HSV-1 assembly and egress are shown. In step 1, the cytoplasmically localized, tegument-coated nucleocapsid undergoes secondary envelopment at the membrane of a cytoplasmic organelle, resulting in a virion within a vesicle. In step 2, the vesicle traffics either to the cell surface (for CFR) or to a cell-cell junction (for CCS), for release by exocytosis.