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. 2021 Dec 22;221(2):e202105060. doi: 10.1083/jcb.202105060

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© 2021 Lu et al.

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Figure 3. — Lipid metabolic pathways revealed in the screens. Genes are annotated in colored circles that show increases (red) or decreases (blue) in cholesterol (upper left), BMP (lower left), cholesterol with U18666A (upper right), or BMP with U18666A (lower right) as indicated. Black arrows indicate trafficking, metabolic routes, and enzymatic reactions. COA, coenzyme A; Chol, cholesterol; GPI, glycophosphatidylinositol; KO, knockout; Lys, lysosome; Per, peroxisome; TCA, tricarboxylic acid.