Table 1.
Demographic and clinical characteristics of DNA10K patient population.
| Inpatient Admissions 2010–2020 a | |||||||
|---|---|---|---|---|---|---|---|
| Overall 10,104 (100) |
No 7750 (76.7) |
Yes 2354 (23.3) |
90-Day Hospital Readmission b | ||||
| N = 2354 | |||||||
| No 2073 (88.1) |
Yes 281 (11.9) |
||||||
| Age, median (IQR) | 50 (39–60) | 50 (40–60) | 48 (38–63) | 47 (37–62) | 59 (44–67) | * | |
| BMI, median (IQR) | 26.7 (23.6–31.1) | 26.6 (23.5–30.8) | 27.5 (23.8–32.1) | * | 27.3 (32.7–31.9) | 28.4 (24.5–33.3) | * |
| Sex | * | * | |||||
| Female | 6684 (66.2) | 4870 (62.8) | 1,814 (77.1) | 1622 (78.2) | 192 (68.3) | ||
| Male | 3420 (33.8) | 2880 (37.2) | 540 (22.9) | 451 (21.8) | 89 (31.7) | ||
| Race | * | * | |||||
| White | 6845 (67.7) | 5117 (66) | 1728 (73.4) | 1510 (72.8) | 218 (77.6) | ||
| Black or African American | 304 (3) | 201 (2.6) | 103 (4.4) | 80 (3.9) | 23 (8.2) | ||
| Asian | 746 (7.4) | 586 (7.6) | 160 (6.8) | 151 (7.3) | 9 (3.2) | ||
| American Indian or Alaska Native | 23 (0.2) | 19 (0.2) | 4 (0.2) | 4 (0.2) | 0 (0) | ||
| Pacific Islander/Hawaiian Native | 3 (0) | 3 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Other | 2,084 (20.6) | 1737 (22.4) | 347 (14.7) | 318 (15.3) | 29 (10.3) | ||
| Declined/Unknown | 99 (1) | 87 (1.1) | 12 (0.5) | 10 (0.5) | 2 (0.7) | ||
| Ethnicity | * | ||||||
| Hispanic/Latino | 497 (4.9) | 374 (4.8) | 123 (5.2) | 112 (5.4) | 11 (3.9) | ||
| Non-Hispanic | 9480 (93.8) | 7259 (93.7) | 2221 (94.4) | 1952 (94.2) | 269 (95.7) | ||
| Declined/Unknown | 127 (1.3) | 117 (1.5) | 10 (0.4) | 9 (0.4) | 1 (0.4) | ||
| Current Patient Status | * | * | |||||
| Alive | 10,083 (99.8) | 7743 (99.9) | 2340 (99.4) | 2067 (99.7) | 273 (97.2) | ||
| Deceased | 21 (0.2) | 7 (0.1) | 14 (0.6) | 6 (0.3) | 8 (2.8) | ||
| Marital Status | * | * | |||||
| Unmarried | 2823 (27.9) | 2232 (28.8) | 591 (25.1) | 492 (23.7) | 99 (35.2) | ||
| Married | 7198 (71.2) | 5439 (70.2) | 1759 (74.7) | 1577 (76.1) | 182 (64.8) | ||
| Unknown | 83 (0.8) | 79 (1) | 4 (0.2) | 4 (0.2) | 0 (0) | ||
| Employee Status | * | * | |||||
| Unemployed | 2899 (28.7) | 2059 (26.6) | 840 (35.7) | 697 (33.6) | 143 (50.9) | ||
| Employed | 6897 (68.3) | 5443 (70.2) | 1454 (61.8) | 1323 (63.8) | 131 (46.6) | ||
| Unknown | 308 (3) | 248 (3.2) | 60 (2.5) | 53 (2.6) | 7 (2.5) | ||
| Smoking Status | |||||||
| No | 9751 (96.5) | 7467 (96.3) | 2284 (97) | 2015 (97.2) | 269 (95.7) | ||
| Yes | 353 (3.5) | 283 (3.7) | 70 (3) | 58 (2.8) | 12 (4.3) | ||
| COVID Status | |||||||
| Yes | 52 (0.5) | 39 (0.5) | 13 (0.6) | 12 (0.6) | 1 (0.4) | ||
| Comorbidities | |||||||
| Cancer | 101 (1) | 44 (0.6) | 57 (2.4) | * | 41 (2) | 16 (5.7) | * |
| COPD | 98 (1) | 44 (0.6) | 54 (2.3) | * | 40 (1.9) | 14 (5) | * |
| Diabetes | 671 (6.6) | 442 (5.7) | 229 (9.7) | * | 182 (8.8) | 47 (16.7) | * |
| History of Diabetes | 740 (7.3) | 479 (6.2) | 261 (11.1) | * | 207 (10) | 54 (19.2) | * |
| Myocardial Infarction | 50 (0.5) | 17 (0.2) | 33 (1.4) | * | 26 (1.3) | 7 (2.5) | |
| Heart Failure | 93 (0.9) | 37 (0.5) | 56 (2.4) | * | 36 (1.7) | 20 (7.1) | * |
| Hypertension | 2074 (20.5) | 1463 (18.9) | 611 (26) | * | 491 (23.7) | 120 (42.7) | * |
| PVD | 83 (0.8) | 35 (0.5) | 48 (2) | * | 35 (1.7) | 13 (4.6) | * |
| Asthma | 940 (9.3) | 655 (8.5) | 285 (12.1) | * | 237 (11.4) | 48 (17.1) | * |
| CVA | 239 (2.4) | 115 (1.5) | 124 (5.3) | * | 91 (4.4) | 33 (11.7) | * |
| CPIC medication order/admin within 30 days prior to admission date in electronic medical record between 12/01/2009 and 12/31/2020 inclusive (N = 2211) | 1935/2211 (87.5) | 276/2211 (12.5) | |||||
| Drug interactions with orders in med Orders/Admin within 30 days prior to inpatient admission | * | ||||||
| Absent | 1337 (69.1) | 169 (61.2) | |||||
| Present | 598 (30.9) | 107 (38.8) | |||||
a Inpatient hospital admissions between 1 January 2010 to 31 December 2020 inclusive. b Readmissions within 90 days of inpatient admission discharge date between 1 January 2010 and 31 March 2021 inclusive. * p-values less than 0.05. Cerebrovascular accident (CVA). Clinical Pharmacogenetics Implementation Consortium (CPIC) (https://cpicpgx.org/, accessed on 22 November 2021). Chronic obstructive pulmonary disease (COPD). Interquartile range (IQR). Peripheral vascular disease (PVD).