Fig. 1.
Neutrophil-specific deletion of Syk enhances long-term functional recovery, but not white matter sparing by 35 days post-SCI. A Greater BMS scores were observed in Sykf/fMRP8-Cre relative to Sykf/f controls starting at 21 days post-SCI. N = 22 for Sykf/f (13F/9M) and 26 for Sykf/fMRP8-Cre (16F/10M). Repeated measures two-way ANOVA with Bonferonni’s post hoc test. B Weight-supported stepping was improved in Sykf/fMRP8-Cre compared to Sykf/f mice. N = 22 for Sykf/f (13F/9M) and 26 for Sykf/fMRP8-Cre (16F/10M). χ2 analysis with Fischer’s exact test. C Representative images of the lesion epicenter, stained with eriochrome cyanine, in Sykf/f and Sykf/fMRP8-Cre. No difference in white matter area was observed at 35 days post-SCI. N = 18 for Sykf/f (13F/5M) and 20 for Sykf/fMRP8-Cre (14F/6M). Unpaired two-tailed Student’s t test. *p < 0.05, **p < 0.01. SCI spinal cord injury, BMS Basso mouse scale