Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 23;9(12):e002843. doi: 10.1136/jitc-2021-002843

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

CD8⁺ T cells mediated the antitumor immunity of VV-scFv-TIGIT. (A) Treatment scheme of H22 ascites model. (B, C) The depletion of CD8⁺ T cells and NK cells in the blood (B) or ascites (C) of mice was analyzed by flow cytometry. (D) Representative diagram of flow cytometric analysis of tumor cells and lymphocytes in the ascites. (E) Flow cytometric analysis of the proportion of tumor cells, lymphocytes, and their subpopulations in the ascites. (F) The levels of cytokines in the ascites were detected by ELISA. (G) Kaplan-Meier survival curves of tumor-bearing mice. ns, no significant differences; *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001. PBS, phosphate-buffered saline; scFv, single-chain variable fragment; TIGIT, T-cell immunoglobulin and ITIM domain; VV, vaccinia virus.