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In this study we establish that Imiquimod (IMQ), Resiquimod (RSQ), and Gardiquimod (GDQ) are substrates of P-gp, and compare P-gp-mediated efflux between Multidrug-Resistant (MDR) cancer cell lines relative to parent cell lines. We also conclude that some efflux likely occurs through other transport proteins as well as passive transport into the extracellular space.
