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. 2021 Dec 10;14(12):1292. doi: 10.3390/ph14121292

Figure 4.

Figure 4

(A) Competitive experiments performed at 37 °C with P-gp substrate Rh123. IMQ leads to an increase in Rh123 accumulation in MDR-derived cancer cells under active transport conditions. Data representative of triplicate experiments. (B) Uptake experiments performed at 4 °C with P-gp substrate, Rhodamine 123. IMQ leads to an increase in Rh123 accumulation in MDR-derived cancer cells under passive diffusion conditions. Data representative of triplicate experiments. p-values were calculated between parent vs. MDR cancer cell type with * p < 0.01, ** p < 0.001 and NS: Not significant.