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. 2021 Dec 24;18:301. doi: 10.1186/s12974-021-02358-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Pericyte heterogeneity in EAE pathology. A The graph represents clinical scores of the three EAE mice that were investigated for this study. The cartoon shows white matter within the cerebellum sagittal sections studied for pericytes. B Confocal images of capillary basement membranes delineated with anti-laminin antibodies exhibit PDGFRβ+ pericytes encased within laminin+ basement membranes in pre-peak (D13), peak (D16) and post-peak (D21) EAE cerebellum. Scale 50 µm. C Pericyte coverage ratio as described by the total length of pericytes along the vasculature shows increase in each of the EAE time points observed as compared to the naïve cerebellar pericytes. D Pericyte density as studied by the nucleated pericytes abutting the length of the vasculature in the given field and represented as number of cells per field of view. Scale 100 µm. Datasets are expressed as mean ± SD. **p < 0.01