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. 2021 Dec 24;18:301. doi: 10.1186/s12974-021-02358-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Pericytes in MS brain. Fresh-frozen MS brains (20 µm thick) harboring active lesions were investigated for pericyte morphologies. A H&E-luxol fast blue (H&E-LFB) staining of an MS brain section from a 60-year-old female showing demyelinating lesions. B, C MS brain section was stained for PDGFRβ and CD45 to locate the pericytes and infiltrating leukocytes in two different lesions demarcated as B and C in panel A. D–F MS tissue from a 61 year old male showing perivascular cuffs (CD45+ cells within laminin+ blood vessel boundaries) and intact PDGFRβ+ cells along the inflamed vasculature in two different brain regions, E and F. G Brain section from a 26 year old MS male also exhibits largely intact PDGFRβ+ staining encased within laminin+ basement membranes (H and I). Arrows show perivascular location of PDGFRβ+ pericytes in 2 regions with CD45+ leukocytes. Scale 100 µm