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. 2021 Dec 14;13(12):2151. doi: 10.3390/pharmaceutics13122151

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CEC of antibiotics from C/S scaffolds; impact of shell biomaterial ink composition. Cumulative CEC release of antibiotics loaded in ALG-MC and ALG-MC-LAP C/S scaffolds (printed with 200/840 C/S needles), quantified by agar diffusion assay (using S. aureus strain; A,C,E) over a period of 7 d. Statistical analysis performed only on burst release, i.e., release of antibiotics at 2 h (n = 3; * p < 0.05; *** p < 0.001). Representative images of ZOI formed on the agar plate when release solutions were added to sample carriers (B,D,F). A cropped image of ZOI of d 7 release sample of gentamicin was performed on a different agar plate and is added onto the ZOI of remaining samples, * in (F).