Release of vancomycin from C/S scaffolds: impact of shell thickness. Schematic diagram showing different coaxial needle combinations (A). Release of vancomycin from ALG-MC scaffolds having different shell thickness (n = 5; ** p < 0.005) (B). Statistical analysis performed only on burst release, i.e., release of antibiotics at 2 h (n = 3; ** p < 0.005). Representative images of ZOI formed in the presence of release solutions collected from scaffolds with different shell thickness after 2 h and 6 h, respectively (C; release solutions obtained from three scaffolds at respective time point were loaded on the sample carrier, denoted by I, II, III).