Figure 2.

6MMPr potentiates antiviral effect of nucleobase but not nucleoside in DENV-infected Huh7 cells. The bar graphs depict the reduction of viral titer promoted by FAV/6MMPr (A), T-1106/6MMPr (C), and T-1105/6MMPr (E) co-treatments. Mean ± SEM of viral titers (PFU/mL) from two independent experiments conducted in duplicate are plotted. “a” indicates significant antiviral activity induced by the nucleobase or the nucleoside alone. * p < 0.05; ** p < 0.005; Black dotted line indicates limit of detection. (B,D,F) show the 3D plots indicating synergistic antiviral effect. Total volume of synergy = TVS. All TVS calculated at 99.9% confidence interval.