Skip to main content
. 2021 Dec 14;13(12):2508. doi: 10.3390/v13122508

Figure 3.

Figure 3

6MMPr increases the C-U and G-A transition frequencies observed in DENV-infected cells treated with T-1105 but not T-1106. Huh7 cells inoculated with DENV (MOI 0.05) were treated with DMSO, 0.1 µM 6MMPr, 52.5 µM T-1105, T-1105/6MMPr combination, 150 µM T-1106, and T-1106/6MMPr combination for 72 hpi. Viral particles from supernatants were concentrated, viral RNA prepared, and the number of substitutions analyzed by NGS. The graphs represent the mean ± SD of the total number of transition (C-U, G-A, U-C, and A-G) identified per 10,000 nt. *, p < 0.05; **, p < 0.005; ns, non-significant; “a”, p < 0.05 compared to T-1105 alone; “b”, p < 0.05 compared to T-1106/6MMPr.