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Adenosine, adenine, and guanosine block the antiviral effect induced by nucleobase/6MMPr combinations. DENV-inoculated Huh7 cells treated with DMSO, T-1105/6MMPr (52.5 µM/0.1 µM) (A,B), or favipiravir/6MMPr (275 µM/0.1 µM) (C,D) in the absence or presence of exogenous nucleosides (A,C) or nucleobases (B,D). The plots represent the mean ± SEM of viral titers expressed as PFU/mL from two independent experiments with samples performed in triplicate. ** p ≤ 0.005.
