Table 4.
Appropriate antibiotic treatment of bacterial CVC-related infection according to isolated pathogens.
| Isolated Pathogen | Catheter Removal | Antibiotic Therapy | |
|---|---|---|---|
| Choice | Duration | ||
| Coagulase-negative staphylococci | Not necessary Risk factor for recurrence |
Vancomycin Oxacillin * Flucloxacillin * Cefazoline * |
Catheter removed: 5–7 days Retained catheter: 10–14 days + ALT 10–14 days |
| St. aureus, St. lugdunensis | Yes | Vancomycin Oxacillin * Flucloxacillin * Cefazoline * |
≥14 days. Necessary to rule out complications. Complications: 4–6 weeks |
| Enterococci | Yes Long-term CVC may retain |
Vancomycin Ampicillin * |
5–14 days. Retained long-term CVC: 7–14 days + ALT 7–14 days |
| gram-negative bacilli | Yes, especially in case of multiresistant bacteria CVC retaining unsuitable for immunosuppressed patients |
Based on severity of disease: Piperacillin/tazobactam *, 4th gen. Cephalosporin *, Carbapenem +/- Aminoglycoside * |
7–14 days |