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. 2021 Dec 16;22(24):13521. doi: 10.3390/ijms222413521

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of adenosine deaminase clearance on THP-1 monocytes proliferation. (a) RNA expression of ADO receptors was investigated in THP-1 cells by Genevestigator software. (b) THP-1 growth rate in medium supplemented with the indicated concentration of eADO. (c) Growth rate of THP-1 in SKOV3 co-culture in the presence of the indicated oncolytic virus (R-LM113, blue; THV_ADA, orange; THV_ADA-SP, green histogram). (d) THP-1 proliferation in THP-1/infected-SKOV3 co-culture assay in the presence of 2 mM ADO. Growth rates for (b–d) were calculated as log (2) of ratio between live THP-1 cells on day 2/day 1. Statistical significance for (b–d) were calculated in comparison to the first sample represented in the chart (No ADO; THP-1 mono-culture; THP-1 mono-culture with 2 mM ADO) and are reported as * for p-value < 0.05; ** for p-value < 0.005 and ns for not statistically significant.