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. 2021 Dec 11;22(24):13330. doi: 10.3390/ijms222413330

Figure 2.

Figure 2

Insulin secretion following 24 h treatment with butyrate and 2.5 µM TSA in BRIN-BD11 cells. The effect of 24 h exposure to (a) sodium butyrate (SB) and (b) 2.5 µM trichostatin A (TSA) on 24 h (chronic) insulin secretion and in response to acute stimulation by 16.7 mM glucose and 10 mM alanine for 20 min (stimulated); (c) the effect of 24 h treatment of sodium butyrate and TSA on BRIN-BD11 cellular insulin content; (d) the percentage of total insulin secreted in response to stimulation per the insulin content of unstimulated cells. Results are means combined from at least 3 independent experiments + SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 compared to the relative untreated control.