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. 2021 Dec 7;22(24):13190. doi: 10.3390/ijms222413190

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of Compound 1-R8 and R8 on yTOPO II relaxation ability. Results of parallel electrophoretic separation of samples from one experiment without the extraction step (A) and with the extraction step (B). Weak DNA–peptide interactions are highlighted with a dotted rectangle. Strong DNA–peptide interactions are highlighted with a dotted ellipse. Supercoiled pBR322 plasmid DNA migration delay is marked with arrows. SC, supercoiled DNA; R, relaxed DNA; T, DNA topoisomers. Data shown are typical of three independent experiments.