Table 2.
Antifungal activity of Compound 1 and its octaarginine conjugate Compound 1-R8 against clinical strains in comparison with C. albicans ATCC 10231. * > Means no activity at the concentration mentioned. The experiments were performed with at least five replicates.
| Compound | * MIC90 (μg mL−1) | ||||||
|---|---|---|---|---|---|---|---|
|
Candida albicans ATCC 10231 |
Candida albicans B3 |
Candida albicans B4 |
Candida albicans Gu4 |
Candida albicans Gu5 |
Candida albicans F2 |
Candida albicans F5 |
|
| Compound 1 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Compound 1-R8 | 0.5 | 2 | 2 | 2 | 2 | 1 | 1 |
| R8 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Fluconazole | 8 | 1 | 16 | 4 | >64 | 8 | >64 |